There is no doubt that the most valuable wealth in humans life is well being. Some of the possbile factors such as unfavorable working conditions, harmful nutrition, stress, exposure of environmental damaging factors and genetic predisposition may damage the health and weel being by causing various diseases. Early diagnosis have a great importance, thus it increases the success of the treatment, quality of life and life time. Therefore, check-up programme plays a vital role particularly for patients who have a familial predisposition or environmental risk for critical disease such as cancer.